Note: in the 'Target' column, ↓ means the target is positively regulated by the regulator, while ↑ indicates negative regulation.
Experimental investigation has been performed.
Bioinformatics investigation has been performed

Regulator ID	Locus tag (Gene)	Related T6SS	Regulator type	Regulatory pathway	Organism	Replicon (Accession)	Coordinates (Strand)	NCBI ID	Target (Regulation)
REG0274	W817_01610 (NplE)	T6SS00937	protein	TCS regulatory pathway	Escherichia coli RS218	chromosome (NZ_CP007149)	214947..215657 (+)	446161331	W817_RS21690 (CpxA) (↓)
REG0338	BN49_RS12735 (phoQ)	T6SS01214	protein	TCS-RR	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	2324171..2325637 (-)	490249900	TssB transcription (↓)
REG0244	ETAE_2059 (phoP)	T6SS00372	protein	TCS-HK	Edwardsiella tarda EIB202	chromosome (NC_013508)	2172565..2173239 (+)	502611910	ETAE_0886 (EsrB) (↓)
REG0323	GT391_RS16925 (phoP)	T6SS01170	protein	TCS-HK	Pectobacterium brasiliense strain 1692	chromosome (NZ_CP047495)	3795787..3796476 (-)	497961604	GT391_RS06470 (expR1) (↑)
REG0339	BN49_RS12735 (phoP)	T6SS01214	protein	TCS-HK	Klebsiella pneumoniae strain Kp52.145	chromosome (NZ_FO834906)	2325637..2326308 (-)	490252783	BN49_2224 (phoQ) (↓)
REG0236	ETAE_3453 (cpxR)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	3641204..3641902 (+)	502613290	ETAE_0886 (esrB) promoter (↓)
REG0273	W817_21870 (CpxR)	T6SS00937	protein	TCS-RR	Escherichia coli RS218	chromosome (NZ_CP007149)	4360812..4361510 (-)	446956464	hcp2B promoter (↓)
REG0241	ETAE_1010 (acrB)	T6SS00372	protein	TCS regulatory pathway	Edwardsiella tarda EIB202	chromosome (NC_013508)	1099309..1102461 (-)	502610875	ETAE_0886 (esrB) promoter (↓)